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An IRF3 activator and adjuvant increases the mRNA expression of the genes encoding ISG54 and OASL in PH5CH8 cells and increases CXCL10 production in phorbol 12-myristate 13-acetate-differentiated THP-1 monocytes at 10 UM immunization with a vaccine in combination with KIN1148 increases blood IgG neutralizing and hemagglutinin antibody titers decreases PFUs in the lungs and lung-draining lymph nodes and increases the survival percentage of mice infected with a lethal dose of influenza virus when used as an adjuvant
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A cardiac glycoside with cardiotonic and antiarrhythmic activities inhibits Na /K -ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 UM for the high- and low affinity human erythrocyte isoenzymes respectively and 1.18 and 28.5 UM for the high- and low affinity porcine cerebral cortex isoenzymes respectively increases contractility and rhythmicity in isolated guinea pig heart in a concentration-dependent manner a degradation product of digoxin
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Potent and selective serotonin uptake inhibitor. Clinically useful antidepressant. Purity: ≥98% (UHPLC). Solubility: Soluble in water (4mg/ml). Long Term Storage: Ambient.
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A steroidal glycoside with diverse biological activities reduces the proliferation of LNCaP and T47D cancer cells (IC50s 32.1 and 27.5 UM respectively) inhibits TNF-a-induced nuclear translocation of NF-KB in HaCaT keratinocytes at 50 nM decreases AST serum levels in a mouse model of carbon tetrachloride-induced liver injury at 0.1 mg/kg topical administration reduces ear epidermal thickness and scaling as well as leukocyte and macrophage infiltration in an imiquimod-induced mouse model of psoriasis at 5 mg/kg
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